REALTIME ONLINE NANOPARTICLE
OF2i technology sets new standards
The paper "Real-Time Nanoparticle Characterization Through Optofluidic Force Induction" by Marko Šimić, Doris Auer, Christian Neuper, Nikola Šimić, Gerhard Prossliner, Ruth Prassl, Christian Hill, and Ulrich Hohenester was published in
Phys. Rev. Applied 18, 024056
WE ARE BRAVE
BRAVE ANALYTICS found its beginnings at the Medical University of Graz within the research project LightMatters. The development of our innovative measurement technology, which enables the characterization of (nano)particles by means of a sophisticated combination of biophotonic and microfluidic forces continuously and in real time, formed the basis of the patented Opto-Fluidic Force Induction (OF2i): our first real-time process analysis sensor BRAVE B1.
HAVE A CLOSER LOOK WITH OF2i
The highly sensitive online and real-time particle characterization method OptoFluidic Force Induction (OF2i) sets particles in motion through actively induced photonic and fluidic forces. The high-speed evaluation of their movements provides statistically relevant process monitoring data (PAT-sensor) such as size, size-distribution and concentration from several microns down to 20nm.
INDUCED MOVEMENT AS A MEASURING PRINCIPLE
MEASUREMENT DATA STREAM
SINGLE PARTICLE ACCURACY &
AUTOMATED & INTEGRABLE
PROCESS ANALYTICAL TOOL
IN REALTIME 24/7
OF2i - INVENTED FOR THE BRAVE
In need of an optimal measurement method which quickly delivers statistically meaningful data?
OF2i continuously measures hundreds of particles per second at concentrations of 10⁸ particles / ml.
Are you looking for an automatable alternative
to the batch sample system?
OF2i can be integrated into the manufacturing process (on-line PAT) and automatically delivers 24/7 measurement data in real time – without time-consuming sample preparation.
Is finding the lowest concentration of particle populations or aggregates your greatest challenge?
OF2i is highly sensitive and offers measurement dynamics from 20nm to over 40μm.
Would you like to recognize the quality
of your samples at a glance?
OF2i enables the direct and live visualization of particles up to 20nm.
Should the adjustment of your measurement dynamics be possible?
Are fingerprints, particle sizes and concentrations common parameters for your production?
OF2i allows the measuring range to be optimally adapted to the required applications because of its active measuring principle.
Resource-saving in terms of time, personnel and waste
Central data acquisition and processing
Meaningful statistical documentation
Easy to handle
Remote control included
BRAVE IN ACTION
Checking the particle sizes and concentrations
Statistically valid data are determined for the interpretation
Measurement for the final, online product release and documentation in real time
Areas of Application:
Process monitoring / controlling
Fine tuning optimization (In Process Quality Control - IPQC)
Identification of Critical Process Parameters (CPP)
Monitoring Critical Quality Attributes (CQA)
Active ingredient control for emulsions such as infusions, painkillers, vaccines, etc.
Extracellular vesicles, aggregation of antibodies
Skin lotions, sunscreen, etc.
BEAUTY & COSMETICS INDUSTRY
PHARMACEUTICAL & BIOTECH INDUSTRY
Surface coatings, pigments
Particle sizes and distribution, for example from nanoplastics