OPTO-FLUIDIC FORCE INDUCTION (OF2i)
Photons carry momentum, spin and angular momentum. And while they are only able to knock out our COO-boxer in our website’s introduction video, they are active and powerful forces in the nanoworld. At BRAVE Analytics we use these intrinsic light-properties – light forces – for our patented OptoFluidic Force Induction OF2i technology to result in active, fast, and continuous online particle characterization. OF2i is arranged as a high throughput counting method for real-time process monitoring. The principle is based on the combination of very defined fluidic as well as optically-induced forces acting on particle streams.
The minimal photonic forces are sufficient to deflect and (de)accelerate small particles from their fluidic induced motion, independent from their overlying Brownian motion. As a result, the induced particle trajectories contain size and shape information. The patented OF2i optical parallelization technology enables and actively sets thousands of particles in motion simultaneously for highly statistically valid readouts.
Single particle visualization (slow motion)
Using an ultramicroscope setup, the actively altered particle trajectories can be determined and translated into characterization data with respect to sizes, size distributions and particle numbers (concentration) with a clear, statistically significant relation to the overall particle population. Due to the underlying active principles of OF2i, our measurements are orders of magnitude faster than Brownian motion processes used in DLS or NTA.
The OF2i technology operates as online and calibration-free process analytical technology (PAT). It is well established at the Medical University of Graz particle lab and tested in cooperation with partners from several industries and research labs.
 Hill, C. Optofluidic force induction (OF2i) - Platform technology for particle characterization and active manipulation in microfluidic environments (Doctoral dissertation). 2018, Medical University Graz.
 Kaneta, T., et al., Theory of optical chromatography. Analytical Chemistry, 1997. 69(14): p. 2701-2710.
A BRAVE VISION
Planned specifications of the measuring sensor – our vision
*dependent on sample
THE BRAVE DIFFERENCE
SOURCE: ISO copyright office, ISO/TR 18196: Technical Report 2016; Nanotechnologies - Measurement technique matrix for the characterization of nano-objects. First Edition: 2016-11-15, Geneva p. 3-5